Research on Structural Design and Mechanical Properties of Biodegradable Cerebrovascular Stents

Abstract

This study presents a systematic investigation into the structural design and mechanical performance optimization of next-generation biodegradable stents specifically engineered for cerebrovascular applications. By addressing critical clinical demands in the treatment of cerebrovascular diseases, the research highlights the limitations of conventional cardiovascular stents, particularly their insufficient flexibility and suboptimal vascular adaptability in delicate cerebral vessels. Through comparative analysis of various structural design methodologies—including modular, non-modular, and hybrid configurations—the study identifies key performance determinants, with a focused examination of support unit geometry and connection unit arrangement. The findings demonstrate the successful development of an innovative stent architecture that integrates axially aligned sinusoidal connection units with strategically distributed discrete support elements. This novel design achieves a remarkable balance between enhanced flexibility and maintained radial strength, overcoming a major trade-off in conventional stent engineering. Furthermore, the research establishes quantitative correlations between critical structural parameters (e.g., strut width, thickness, and unit spacing) and performance metrics such as bending compliance and radial support capability, providing a robust theoretical framework for optimized stent design. To validate these advancements, the study introduces a comprehensive finite element analysis (FEA)-based evaluation methodology, enabling precise assessment of stent performance under simulated physiological conditions. These insights not only advance the field of biodegradable stent technology but also offer practical technical guidance for future research and development. Ultimately, this work contributes significantly to the evolution of specialized stent systems tailored for the unique biomechanical challenges of cerebrovascular disease intervention.