Therapeutic Potential of Non-Coding RNAs in Cancer

Authors

  • Shuangshuang Xu Department of Medical Records, The Second Affiliated Hospital of Shandong First Medical University Author
  • Guopeng Zhang The Second Affiliated Hospital of Shandong First Medical University Author
  • Guanghao Li Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China. Author https://orcid.org/0000-0001-9684-4037

DOI:

https://doi.org/10.63174/xdi.GJZE9364

Keywords:

Non-coding RNAs (ncRNAs), Cancer Therapeutics, Metabolic Reprogramming

Abstract

Non-coding RNAs (ncRNAs) have emerged as crucial players in the landscape of cancer biology, challenging the long-held paradigm that primarily focused on protein-coding genes. The human genome is predominantly transcribed into non-coding RNAs, which do not encode proteins but instead participate in a myriad of regulatory functions vital for cellular homeostasis and pathology. Recent advancements in genomics and molecular biology have unveiled the complexity and diversity of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and PIWI-interacting RNAs (piRNAs). In this review, the mechanisms by which ncRNAs influence cancer biology and their potential therapeutic applications will be explored in depth.

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Published

2025-05-17

Issue

Vol. 1 No. 2 (2025)

Section

Review

License

Articles published in X-Disciplinarity are open access and licensed under the Creative Commons Attribution–NonCommercial–NoDerivatives 4.0 International License. Under this license, authors retain copyright and grant the journal the right to publish the work while allowing others to copy and share it for non-commercial purposes, provided that appropriate credit is given and the work is not altered or transformed.

How to Cite

(1)
Therapeutic Potential of Non-Coding RNAs in Cancer. XDI 2025, 1 (2), 4. https://doi.org/10.63174/xdi.GJZE9364.